Acute O2 sensing through HIF2α-dependent expression of atypical cytochrome oxidase subunits in arterial chemoreceptors
نویسندگان
چکیده
منابع مشابه
The role of NADPH oxidase in carotid body arterial chemoreceptors.
O(2)-sensing in the carotid body occurs in neuroectoderm-derived type I glomus cells where hypoxia elicits a complex chemotransduction cascade involving membrane depolarization, Ca(2+) entry and the release of excitatory neurotransmitters. Efforts to understand the exquisite O(2)-sensitivity of these cells currently focus on the coupling between local P(O2) and the open-closed state of K(+)-cha...
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Airway neuroepithelial bodies sense changes in inspired O2, whereas arterial O2 levels are monitored primarily by the carotid body. Both respond to hypoxia by initiating corrective cardiorespiratory reflexes, thereby optimising gas exchange in the face of a potentially deleterious O2 supply. One unifying theme underpinning chemotransduction in these tissues is K+ channel inhibition. However, th...
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Vertebrate mitochondrial cytochrome c oxidase (COX) possesses 10 nuclear-encoded subunits. Six subunits have paralogs in mammals, but the origins and distribution of isoforms among vertebrates have not been analyzed. We used Bayesian phylogenetic analysis to interpret the origins of each subunit, inferring the roles of gene and genome duplications. The paralogous ancestries of five genes were i...
متن کاملDual-mode EPR spectrometry of O2-pulsed cytochrome c oxidase.
O2-activated bovine heart cytochrome c oxidase has been examined by dual-mode EPR spectrometry. Resonances have been observed at g = 10 and 4.5 in the parallel mode and at g = 10, 5, 1.8 and 1.7 in the normal mode. The bulk of these signals are interpreted to come from a stoichiometric S = 2 system with magnitude of a = 0.17 cm-1, D = +2.1 cm-1, magnitude of E = 0.026 cm-1, g = 2. Exchange coup...
متن کاملCezanne regulates E2F1-dependent HIF2α expression
Mechanisms regulating protein degradation ensure the correct and timely expression of transcription factors such as hypoxia inducible factor (HIF). Under normal O2 tension, HIFα subunits are targeted for proteasomal degradation, mainly through vHL-dependent ubiquitylation. Deubiquitylases are responsible for reversing this process. Although the mechanism and regulation of HIFα by ubiquitin-depe...
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ژورنال
عنوان ژورنال: Science Signaling
سال: 2019
ISSN: 1945-0877,1937-9145
DOI: 10.1126/scisignal.aay9452